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  "Title": "Calculate the 'Grantham' Distance",
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  "Authors@R": "c(\nperson(given = \"Ramiro\", family = \"Magno\",\nemail = \"ramiro.magno@gmail.com\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0001-5226-3441\")),\nperson(given = \"Isabel\", family = \"Duarte\",\nemail = \"iduarte.scientist@gmail.com\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0003-0060-2936\")),\nperson(given = \"Ana-Teresa\", family = \"Maia\",\nemail = \"maia.anateresa@gmail.com\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-0454-9207\")),\nperson(\"CINTESIS\",\nrole = c(\"cph\", \"fnd\"))\n)",
  "Description": "A minimal set of routines to calculate the 'Grantham'\ndistance <doi:10.1126/science.185.4154.862>. The 'Grantham'\ndistance attempts to provide a proxy for the evolutionary\ndistance between two amino acids based on three key chemical\nproperties: composition, polarity and molecular volume. In\nturn, evolutionary distance is used as a proxy for the impact\nof missense mutations. The higher the distance, the more\ndeleterious the substitution is expected to be.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
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  "BugReports": "https://github.com/maialab/grantham/issues",
  "Language": "en-US",
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  "Repository": "https://ramiromagno.r-universe.dev",
  "Date/Publication": "2024-07-30 22:24:14 UTC",
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    "User": "root"
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
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    "extra/manual.pdf",
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    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
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  "_homeurl": "https://github.com/patterninstitute/grantham",
  "_realowner": "patterninstitute",
  "_cranurl": false,
  "_releases": [
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      "date": "2021-12-20"
    },
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      "date": "2022-01-07"
    },
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      "date": "2024-07-30"
    },
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      "date": "2025-05-31"
    },
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      "date": "2025-05-31"
    }
  ],
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    "%>%",
    "amino_acid_pairs",
    "amino_acids",
    "as_one_letter",
    "as_three_letter",
    "grantham_distance",
    "grantham_distance_exact",
    "grantham_distance_original",
    "grantham_equation"
  ],
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      "name": "amino_acids_properties",
      "title": "Amino acid side chain property values",
      "object": "amino_acids_properties",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "amino_acid",
        "c",
        "p",
        "v"
      ],
      "rows": 20,
      "table": true,
      "tojson": true
    },
    {
      "name": "grantham_distances_matrix",
      "title": "Grantham distance matrix",
      "object": "grantham_distances_matrix",
      "class": [
        "matrix",
        "array"
      ],
      "fields": [
        "Ser",
        "Arg",
        "Leu",
        "Pro",
        "Thr",
        "Ala",
        "Val",
        "Gly",
        "Ile",
        "Phe",
        "Tyr",
        "Cys",
        "His",
        "Gln",
        "Asn",
        "Lys",
        "Asp",
        "Glu",
        "Met",
        "Trp"
      ],
      "rows": 20,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "amino_acid_pairs",
      "title": "Generate amino acid pairs",
      "topics": [
        "amino_acid_pairs"
      ]
    },
    {
      "page": "amino_acids",
      "title": "The 20 standard amino acids",
      "topics": [
        "amino_acids"
      ]
    },
    {
      "page": "amino_acids_properties",
      "title": "Amino acid side chain property values",
      "topics": [
        "amino_acids_properties"
      ]
    },
    {
      "page": "as_one_letter",
      "title": "Convert three-letter amino acid codes to one-letter codes",
      "topics": [
        "as_one_letter"
      ]
    },
    {
      "page": "as_three_letter",
      "title": "Convert one-letter amino acid codes to three-letter codes",
      "topics": [
        "as_three_letter"
      ]
    },
    {
      "page": "grantham_distance",
      "title": "Grantham distance",
      "topics": [
        "grantham_distance"
      ]
    },
    {
      "page": "grantham_distances_matrix",
      "title": "Grantham distance matrix",
      "topics": [
        "grantham_distances_matrix"
      ]
    },
    {
      "page": "grantham_equation",
      "title": "Grantham distance",
      "topics": [
        "grantham_equation"
      ]
    }
  ],
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